![]() ![]() Upon mechanical stress, expression levels of Lamin-A and -C change rapidly to minimise nuclear damage and defects in a cell cycle, which could otherwise lead to diseases such as chronic inflammation, cancer and Alzheimer’s disease. These collaborations will ensure that we can successfully complete the project and exploit these new developments.Ĭellular adaptation to mechanical strain (mechano-adaptation) is increasingly understood to be conferred by Lamin intermediate filament proteins located within the nuclear lamina. ![]() ![]() Our exciting recent discoveries in this rapidly evolving field have led us to establish new collaborations with Aarhus University (Denmark), Ri.MED Foundation (Italy) and Newcastle University. This project will generate insight into fundamental processes of cellular mechano-adaptation, which plays a critical role in formation, maintenance, and regeneration of our body. institute-of-life-course-and-medical-sciences.Biological and Medical Sciences Studying in: ![]()
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